Results of treatment of patients with nasopharyngeal cancer after superselective chemoembolization of tumor vessels

Background. Radiation therapy for locally advanced nasopharyngeal carcinoma (NC) has a high incidence of fatal complications, which leads to absolute contraindications External Beam Therapy (EBRT). Chemoembolization tumor significantly reduces these risks and allows EBRT. The aim this study was assess response rate after chemoembolization Objective. To evaluate the in patients with cancer treated vessels external beam radiation combination chemotherapy. Methods. Prospective descriptive conducted. Patients cT3–4, N0–2, M0 NC April 2016 – March 2021 were enrolled. All had doxorubicin’s microspheres followed by EBRT administrated once daily (2,0 Gy per fraction). Treatment assessed according RECIST 1.1 criteria three weeks. Results. Twenty-one identified. median age 47 years (IQR: 20–60). Tumors staged as cT3N0M0 1 (4.8%) case, cT3N1M0 6 (28.6%) cases, cT3N2M0 5 (23.8%) cT4N0M0 cT4N1M0 case cT4N2M0 7 (33.4%) cases. There following histopathology types NC: WHO type I (n = 1), II 7) III 13). Fourteen (66.7%) EBV-non-associated EBV-associated. Twenty (95.2%) chemoembolization. Complete (CR) achieved 3 (14.3%) patients, partial (PR) 4 (19%) stabilization 12 (57.1%), progression 2 (9.6%) patients. 21 (median total dose 66 [IQR: 60–72]).CR 17 (80%) (20%) Conclusions. provides acceptable Further studies are needed local control.